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 Wissenschaftlicher Werdegang
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| 1987-1991 | Study of Pharmcy at the Free University Berlin, Germany | | 1991-1992 | Practical work St. Rochus Pharmacy, Berlin | | 1993-1997 | PhD Student, Institute for Pharmacy, Free University Berlin and Institute for Pharmaceutical Chemistry, Heinrich-Heine-University Düsseldorf | | 1997 | PhD thesis (Summa cum laude) "Molecular modelling studies on histamine H2- and H3-receptor ligands" | | 1997-1998 | Postdoc with Prof. Dr. C. Wermuth, Institute de Pharmacie Universite Louis-Pasteur, Strasbourg | | 1998-2002 | Habilitation "Development of novel 3D QSAR techniques for structure-based drug design", Heinrich Heine University Düsseldorf, Germany | | 2001 | Research stay, Prof. Dr. H. Kubinyi, BASF AG, Ludwigshafen, Germany | | July 2002 | Venia legendi for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine University Düsseldorf, Germany | | July 2003 | Full Professor for Pharmaceutical and Medicinal Chemistry, Martin-Luther-University Halle, Germany |
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Expertenprofil |
Medizinische Chemie- Cheminformatics
- Molecular Modelling
- Wirkstoffdesign
- Wirkstoffsynthese
- Virtuelles Screening
- Strukturbasierte Wirkstoffoptimierung
- Histonmodifizierende Proteine
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| Serviceangebot |
- Virtuelles Screening nach Leitstrukturen für Proteintargets
- Computerbasierte Optimierung von Wirkstoffen
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| 2009 | Spannhoff, Astrid; Sippl, Wolfgang; Jung, Manfred * Cancer treatment of the future: Inhibitors of histone methyltransferases In: The international journal of biochemistry & cell biology . - Amsterdam : Elsevier, Bd. 41.2009, 1, S. 4-11, insges. 8 S. Artikel in Zeitschriften |
Göllner, Christiane; Philipp, Claudia; Dobner, Bodo; Sippl, Wolfgang; Schmidt, Matthias * First total synthesis of 1,2-dipalmitoyl-3-(N-palmitoyl-6 -amino-6 -deoxy-a- -d-glucosyl)-sn-glycerola glycoglycerolipid of a marine alga with a high inhibitor activity against human Myt1-kinase In: Carbohydrate research . - Amsterdam : Elsevier, Bd. 344.2009, 13, S. 1628-1631, insges. 4 S. Artikel in Zeitschriften |
Schemies, Jörg; Sippl, Wolfgang; Jung, Manfred * Histone deacetylase inhibitors that target tubulin In: Cancer letters . - Amsterdam : Elsevier, Bd. 280.2009, 2, S. 222-232, insges. 11 S. Artikel in Zeitschriften |
Dubreuil, Patrice; Letard, Sébastien; Ciufolini, Marco; Gros, Laurent; Humbert, Martine; Castéran, Nathalie; Borge, Laurence; Hajem, Bérengère; Lermet, Anne; Sippl, Wolfgang * Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT In: Public Library of Science : PLoS one . - Lawrence, Kan. : PLoS, Bd. 4.2009, S. 7258, Link unter URL Artikel in Zeitschriften |
Schäfer, Stefan; Saunders, Laura; Schlimme, Sonja; Valkov, Vassil; Wagner, Julia M.; Kratz, Felix; Sippl, Wolfgang; VErdin, Eric; Jung, Manfred * Pyridylalanine-containing hydroxamine acids as selective HDAC6 inhibitors In: ChemMedChem . - Weinheim : Wiley-VCH, Bd. 4.2009, S. 283-290 Artikel in Zeitschriften |
Wichapong, Kanin; Lindner, Marc; Pianwanit, Somsak; Kokpol, Sirirat; Sippl, Wolfgang * Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors In: European journal of medicinal chemistry . - Paris : EDIFOR, Bd. 44.2009, 4, S. 1383-1395, insges. 13 S. Artikel in Zeitschriften |
Spannhoff, Astrid; Hauser, Alexander-Thomas; Heinke, Ralf; Sippl, Wolfgang; Jung, Manfred * The emerging therapeutic potential of histone Methyltransferase and Demethylase inhibitors In: ChemMedChem . - Weinheim : Wiley-VCH, Bd. 4.2009, 10, S. 1568-1582 Artikel in Zeitschriften |
Heinke, Ralf; Spannhoff, Astrid; Meier, Rene; Trojer, Patrick; Bauer, Ingo; Jung, Manfred; Sippl, Wolfgang * Virtual Screening and Biological Characterization of Novel Histone Arginine Methyltransferase PRMT1 Inhibitors In: ChemMedChem . - Weinheim : Wiley-VCH, Bd. 4.2009, 1, S. 69-77, insges. 9 S. Artikel in Zeitschriften |
da Cunha, Elaine Fontes Ferreira; Sippl, Wolfgang; de Castro Ramalho, Teodorico; Ceva Antunes, Octavio Augusto; de Alencastro, Ricardo Bicca; Albuquerque, Magaly Girão * 3D-QSAR CoMFA-CoMSIA models based on theoretical active conformers of HOE-BAY-793 analogs derived from HIV-1 protease inhibitor complexes In: European journal of medicinal chemistry . - Paris : EDIFOR, Bd. 44.2009, 11, S. 4344-4352 Artikel in Zeitschriften |
| 2008 | Küblbeck, Jenni; Jyrkkärinne, Johanna; Poso, Antti; Turpeinen, Miia; Sippl, Wolfgang; Honkakoski, Paavo; Windshügel, Björn * Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor In: Biochemical pharmacology . - New York, NY : Elsevier, Bd. 76.2008, 10, S. 1288-1297, insges. 10 S. Artikel in Zeitschriften |
Jung, Manfred; Neugebauer, Robert C.; Sippl, Wolfgang * Inhibitors of NAD+ Dependent Histone Deacetylases (Sirtuins) In: Current pharmaceutical design . - Hilversum : Bentham Science Publ., Bd. 14.2008, 6, S. 562-573, insges. 12 S. Artikel in Zeitschriften |
Jyrkkärinne, Johanna; Windshügel, Björn; Rönkkö, Toni; Tervo, Anu J.; Küblbeck, Jenni; Lahtela-Kakkonen, Maija; Sippl, Wolfgang; Poso, Antii; Honkakosi, Paavo * Insights into Ligand-Elicited Activation of Human Constitutive Androstane Receptor Based on Novel Agonists and Three-Dimensional Quantitative Structure-Activity Relationship In: Journal of medicinal chemistry . - Easton, Pa. : American Chemical Society, Bd. 51.2008, 22, S. 7181-7192 Artikel in Zeitschriften |
Wollmann, Jörg; Baumert, Christiane; Erlenkamp, German; Sippl, Wolfgang; Hilgeroth, Andreas * Novel insight into inhibitor binding of highly symmetric HIV-1 protease In: ChemBioChem . - Weinheim : Wiley-VCH Verl., Bd. 9.2008, S. 874-878 Artikel in Zeitschriften |
Schäfer, Stefan; Saunders, Laura; Eliseeva, Elena; Velena, Alfredo; Jung, Mira; Schwienhorst, Andreas; Strasser, Anja; Dickmanns, Achim; Ficner, Ralf; Schlimme, Sonja; Sippl, Wolfgang; Verdin, Eric; Jung, Manfred * Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs) In: Bioorganic & medicinal chemistry letters . - New York, NY [u.a.] : Pergamon, Elsevier Science, Bd. 16.2008, 4, S. 2011-2033, insges. 23 S. Artikel in Zeitschriften |
Neugebauer, Robert C.; Uchiechowska, Urszula; Meier, Rene; Hruby, Henning; Valkov, Vassil; Verdin, Eric; Sippl, Wolfgang; Jung, Manfred * Structure-Activity Studies on Splitomicin Derivatives as Sirtuin Inhibitors and Computational Prediction of Binding Mode In: Journal of medicinal chemistry . - Easton, Pa. : American Chemical Society, Bd. 51.2008, 5, S. 1203-1213, insges. 11 S. Artikel in Zeitschriften |
Uciechowska, Urszula; Schemies, Joerg; Neugebauer, Robert C.; Huda, Elisabeth-Maria; Schnitt, Martin L.; Meier, Rene; VErdin, Eric; JUng, Manfred; Sippl, Wolfgang * Thiorbarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing In: ChemMedChem . - Weinheim : Wiley-VCH, Bd. 3.2008, 12, S. 1965-1976 Artikel in Zeitschriften |
| 2007 | Spannhoff, Astrid; Machmur, Rospita; Heinke, Ralf; Trojer, Patrick; Bauer, Ingo; Brosch, Gerald; Schüle, Roland; Hanefeld, Wolfgang; Sippl, Wolfgang; Jung, Manfred * A novel arginine methyltransferase inhibitor with cellular activity In: Bioorganic & medicinal chemistry letters . - New York, NY [u.a.] : Pergamon, Elsevier Science, Bd. 17.2007, 15, S. 4150-4153, insges. 4 S. Artikel in Zeitschriften |
Windshügel, Björn; Jyrkkärinne, Johanna; Vanamo, Jenni; Poso, Antti; Honkakoski, Paavo; Sippl, Wolfgang * Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity In: Journal of molecular graphics and modelling . - New York, NY : Elsevier, Bd. 25.2007, 5, S. 644-657, insges. 14 S. Artikel in Zeitschriften |
Schlegel, Birgit; Laggner, Christian; Meier, Rene; Langer, Thierry; Schnell, David; Seifert, Roland; Stark, Holger; Höltje, Hans-Dieter; Sippl, Wolfgang * Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening /Birgit Schlegel; Christian Laggner; Rene Meier; Thierry Langer; David Schnell; Roland Seifert; Holger Stark; Hans-Dieter Höltje; Wolfgang Sippl In: Journal of computer aided molecular design . - Dordrecht : Springer/ESCOM, Bd. 21.2007, 8, S. 437-454, insges. 18 S. Artikel in Zeitschriften |
Bichlmaier, Ingo; Finel, Moshe; Sippl, Wolfgang; Yli-Kauhaluoma, Jari * Stereochemical and steric control of UDP-glucuronosyltransferase-catalyzed conjugation reaction. A rational approach for the design of inhibitors for the human UGT2B7 In: ChemMedChem . - Weinheim : Wiley-VCH, Bd. 2.2007, 12, S. 1730-1740 Artikel in Zeitschriften |
Trapp, Johannes; Meier, Rene; Honigwiset, Darunee; Kassack, Matthias U.; Sippl, Wolfgang; Jung, Manfred * Structure-activiity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins) In: ChemMedChem . - Weinheim : Wiley-VCH, Bd. 2.2007, 10, S. 1419-1431 Artikel in Zeitschriften |
Spannhoff, Astrid; Heinke, Ralf; Bauer, Ingo; Trojer, Patrick; Metzger, Eric; Gust, Rronald; Schüle, Roland; Brosch, Gerald; Sippl, Wolfgang; Jung, Manfred * Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases In: Journal of medicinal chemistry . - Easton, Pa. : American Chemical Society, Bd. 50.2007, 10, S. 2319-2325, insges. 7 S. Artikel in Zeitschriften |
| 2006 | Trapp, Johannes; Jochum, Anne; Meier, Rene; Saunders, Laura; Marshall, Brett; Kunick, Conrad; Verdin, Eric; Goekjian, Peter; Sippl, Wolfgang; Jung, Manfred * Adenosine mimetics as inhibitors of Nad+-dependent histone deacetylases, from kinase to sirtuin inhibition In: Journal of medicinal chemistry . - Easton, Pa. : American Chemical Society, Bd. 49.2006, S. 7307-7316 Artikel in Zeitschriften |
Sippl, Wolfgang * Application of structure-based alignment methods for 3D QSAR analyses In: Pharmacophores and pharmacophore searches . - Weinheim : WILEY-VCH, 2006, S. 223-249 Monographiebeitrag |
Frohberg, Petra; Wagner, Christoph; Meier, Rene; Sippl, Wolfgang * Derivatives of arylhydrazonic acids. Part 3:Stereochemical rearrangement of Z-oxanilo-N1-dialkyl-arylamidrazones In: Tetrahedron . - Kidlington : Elsevier Science, Bd. 62.2006, 25, S. 6050-6060 Artikel in Zeitschriften |
Sippl, Wolfgang * 3D-QSAR using the GRID/GOLPE approach In: Molecular interaction fields . - Weinheim : WILEY-VCH, 2006, S. 145-170 Monographiebeitrag |
| 2005 | Jyrkkärinne, Johanna; Windshügel, Björn; Mäkinen, Janne; Ylisirniö, Markku; Peräkylä, Mikael; Poso, Antti; Sippl, Wolfgang; Honkakoski, Paavo * Amino acids important for ligand specificity of the human constitutive androstane receptor In: The journal of biological chemistry. - Bethesda, Md. : ASBMB, Bd. 280.2005, 7, S. 5960-5971 Artikel in Zeitschriften |
Meier, Rene; Sippl, Wolfgang * Impact of scoring functions on the results of molecular docking studies In: User Meeting // Chemical computing group ; 19-20 Septmeber 2005. - Köln, insges. P09 S. Artikel in Konferenzbänden |
Windshügel, B.; Sippl, Wolfgang * In Silico Proteinsimulation: fact or fantasy? In: Bioforum. - Darmstadt : GIT-Verl., 2005, 7-8, S. 54-55 Artikel in Zeitschriften |
Schlegel, B.; Stark, H.; Sippl, Wolfgang; Höltje, H.-D. * Model of a specific human histamine H3 receptor (hH3R)) binding pocket suitable for virtual drug design In: Inflammation research. - Berlin : Birkhäuser, Bd. 54.2005, S1, S. S50-S51 Artikel in Zeitschriften |
Schlimme, Sonja; Jung, M.; Sippl, Wolfgang * Molecular dynamics simulations and docking studies on histone deacetyclases In: Abstracts. - Leipzig, 2005, S. 15 Artikel in Konferenzbänden |
Schlimme, Sonja; Jung, Manfred; Sippl, Wolfgang * Molecular dynamics simulations and docking studies on histone deacetylases In: Divide & Conquer: Assembling leads from Fragments - disassembling protein complexes. - Ebsdorfergrund-Rauischholzhausen, 2005, S. 39 Artikel in Konferenzbänden |
Schlegel, Birgit; Sippl, Wolfgang; Höltje, Hans-Dieter * Molecular dynamics simulations of bovine rhodopsin: influence of protonation states and different In: Journal of molecular modeling. - Berlin : Springer, 2005, Bd. 12.2004, S. 49-64 Artikel in Zeitschriften |
Windshügel, Björn; Jyrkkärinne, Johanna; Poso, Antti; Honkakoski, Paavo; Sippl, Wolfgang * Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering th molecular basis for constitutive activity In: Journal of molecular modeling. - Berlin : Springer, Bd. 11.2005, S. 69-79 Artikel in Zeitschriften |
windshügel, Björn; Jyrkkärinne, Johanna; Honkakoski, Paavo; Sippl, Wolfgang * The basal activity of constitutive androstane receptor (CAR) - homology modelling versus crystallisation In: Divide & Conquer: Assembling leads from Fragments - disassembling protein complexes. - Ebsdorfergrund-Rauischholzhausen, 2005, S. 45 Artikel in Konferenzbänden |
| 2004 | Stark, Holger; Kathmann, Markus; Schlicker, Eberhard; Schunack, Walter; Schlegel, Birgit; Sippl, Wolfgang * Medicinal chemical and pharmacological aspects of Imidazole-containing histamine H3 receptor antagonists In: Mini-reviews in ... medicinal chemistry. - Hilversum, the Netherlands [u.a.] : Bentham Science Publ.. - Bd. 4.2004, S. 965-977 Artikel in Zeitschriften |
Schlimme, Sonja; Jung, M.; Sippl, Wolfgang * Molecular dynamics simulations of the human histone deacetylase 1 (HDAC1) In: 18. Darmstädter Molecular Modelling Workshop: Computer-Cehmie-Centrum Erlangen 18.Mai und 19.Mai 2004. - Erlangen. - 2004, S. 69 Artikel in Konferenzbänden |
Windshügel, Björn; Poso, Antti; Honkakoski, Paavo; Sippl, Wolfgang * The constitutive activity of CAR examined by MD simulation In: 18. Darmstädter Molecular Modelling Workshop: Computer-Cehmie-Centrum Erlangen 18.Mai und 19.Mai 2004. - Erlangen. - 2004, S. 41-42 Artikel in Konferenzbänden |
| 2003 | Höltje, Hans-Dieter; Sippl, Wolfgang * Molecular modeling : basic principles and applications Weinheim : Wiley-VCH, 2003. - XII, 228 S. : Ill., graph. Darst. ; 240 mm x 170 mm Herausgeberschaft |
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